Research Article
Year 2022,
Volume: 4 Issue: 4, 374 - 379, 22.10.2022
Abstract
References
- Molodecky NA, Soon IS, Rabi DM, et al. Increasing incidence and prevalence of the inflammatory bowel diseases with time, based on systematic review. Gastroenterology 2012; 142: 46-54.
- Lewis JD, Chuai S, Nessel L, Lichtenstein GR, Aberra FN, Ellenberget JH. Use of the noninvasive components of the Mayo score to assess clinical response in ulcerative colitis. Inflamm Bowel Dis 2008; 14: 1660–6.
- Kornbluth A, Sachar DB. Ulcerative colitis practice guidelines in adult (update). Am J Gastroenterol 2004; 99: 1371-85.
- Sadeghian M, Saneei P, Siassi F, Esmaillzadeh A. Vitamin D status in relation to Crohn’s disease: a meta-analysis of observational studies. Nutrition 2016; 32: 505-14.
- Garg M, Lubel JS, Sparrow MP, Holt SG, Gibson PR. Review article: vitamin D and inflammatory bowel disease: established concepts and future directions. Aliment Pharmacol Ther 2012; 36: 324-44.
- Holick MF. McCollum award lecture, vitamin D: new horizons for the 21st century. Am J Clin Nutr 1994; 60: 619-30.
- Trang H, Cole DE, Rubin LA, Pierres A, Siu S. Evidence that VİTD3 increases serum 25 hydroxyvitamin D more efficiently than does vitamin D2. Am J Clin Nutr 1998; 68: 854-8.
- Nesby-O’Dell S, Scanlon KS, Cogswell ME, Gillespie C, Holli BW. Hypovitaminosis D prevalence and determinants among African American and white women of reproductive age. Third National Health and Nutrition Examination. Am J Clin Nutr 2002; 76: 187-92.
- Zaccardi F, Rocca B, Pitocco D, Tanese L, Rizzi A. Platelet mean volume, distribution width, and count in type 2 diabetes, impaired fasting glucose, and metabolic syndrome: a meta-analysis. Diabetes Metab Res Rev 2015; 31: 402–10.
- Akturk S, Buyukavci R. Evaluation of blood neutrophil-lymphocyte ratio and platelet distribution width as inflammatory markers in patients with fibromyalgia. Clin Rheumatol 2017; 36: 1885-89.
- Chu SG, Becker RC, Berger PB, Bhatt DL, Eikelboom JW. Mean platelet volume as a predictor of cardiovascular risk: A systematic review and meta-analysis. J Thromb Haemost 2010; 8: 148–56.
- Munger KLM, Zhang SM, O’Reilly E. Vitamin D intake and incidence of multiple sclerosis. Neurology 2004; 62: 60-5.
- Raman M, Milestone AN, Walters JR, Hart AL, Ghosh S. Vitamin D and gastrointestinal diseases: inflammatory bowel disease and colorectal cancer. Ther Adv Gastroenterol 2011; 4: 49-62.
- Travis SP, Higgins PD, Orchard T, et al. Review article: defining remission in ulcerative colitis. Aliment Pharmacol Ther 2011; 34: 113-24.
- Holick MF. Vitamin D deficiency. N Engl J Med 2007; 357: 266-81.
- Cetin M, Bakirci EM, Baysal E, Tasolar H, Balli M. Increased platelet distribution width is associated with ST-segment elevation myocardial infarction and thrombolysis failure. Angiology 2014; 65: 737-43.
- Dastjerdi MS, Emami T, Najafian A, Amini M. Mean platelet volume measurement, EDTA or citrate? Hematology 2006; 11: 317-19.
- Kowara M, Grodecki K, Huczek Z, Puchta D, Paczwa K. Platelet distribution width predicts left ventricular dysfunction in patients with acute coronary syndromes treated with percutaneous coronary intervention. Kardiol Pol 2017; 75: 42-47.
- Yang SW, Cho SH, Kwon HS, Sohn IS, Hwang HS. The significance of the platelet distribution width as a severity marker for the development of preeclampsia. Eur J Obstet Gynecol Reprod Biol 2014; 175: 107-11.
- Dinc B, Oskay A, Dinc SE, Bas B, Tekin S. New parameter in the diagnosis of acute appendicitis: platelet distribution width. World J Gastroenterol 2015; 21: 1821-26.
- Bath PM, Butterworth RJ. Platelet size: Measurement, physiology and vascular disease. Blood Coagul Fibrinolysis 1996; 7: 157-61.
- Kisacik B, Tufan A, Kalyoncu U, Karadag O, Akdogan A. Mean platelet volume (MPV) as an inflammatory marker in ankylosing spondylitis and rheumatoid arthritis. Joint Bone Spine 2008; 75: 291-94.
- Kapsoritakis AN, Koukourakis MI, Sfiridaki A, Potamianos SP, Kosmadaki MG. Mean platelet volume: A useful marker of inflammatory bowel disease activity. Am J Gastroenterol 2001; 96: 776-81.
- Jaremo P, Sandberg-Gertzen H. Platelet density and size in inflammatory bowel disease. Thromb Haemost 1996; 75: 560-61.
- Ginde AA, Mansbach JM, Camargo Jr Ca. Association between serum 25 hydroxyvitamin D level and upper respiratory tract infection in the Third National Health and Nutrition Examination Survey. Arch Intern Med 2009; 169: 384-90.
- Collins CE, Rampton DS, Rogers J, Williams NS. Platelet aggregation and neutrophil sequestration in the mesenteric circulation in inflammatory bowel disease. Eur J Gastroenterol Hepatol 1997; 9: 1213-17.
- Kapsoritakis AN, Koukourakis MI, Sfiridaki A, et al. Mean platelet volume: A useful marker of inflammatory bowel disease activity. Am J Gastroenterol 2001; 96: 776-81.
- Munger KLM, Zhang SM, O’Reilly E. Vitamin D intake and incidence of multiple sclerosis. Neurology 2004; 62: 60-5.
- Merlino LA, Curtis J, Mikuls TR. Vitamin D intake is inversely associated with rheumatoid arthritis: results from the Iowa Women’s Health Study. Arthritis Rheum 2004; 50: 72-7.
- Caraba A, Crisan V, Romosan I, Mozos I, Murariu M. Vitamin D status, disease activity, and endothelial dysfunction in early rheumatoid arthritis patients. Dis Markers 2017; 2017: e5241012.
- Carvalho JTG, Schneider M, Cuppari L. Cholecalciferol decreases inflammation and improves vitamin D regulatory enzymes in lymphocytes in the uremic environment: A randomized controlled pilot trial. PLoS One 2017; 12: e0179540.
- Hassan V, Hassan S, Seyed-Javad P. Association between serum 25 (OH) vitamin D concentrations and inflammatory bowel diseases (IBDs) activity. Med J Malaysia 2013; 68: 34–8.
- Limketkai BN, Bayless TM, Brant SR. Lower regional and temporal ultraviolet exposure is associated with increased rates and severity of inflammatory bowel disease hospitalization. Aliment Pharmacol Ther 2014; 40: 508–17.
- Dolatshahi S, Pishgar E, Jamali R. Does serum 25 hydroxyvitamin D level predict disease activity in ulcerative colitis patients? Int J Clin Lab Med 2016; 20: 10-5.
The relationship between ulcerative colitis activity and vitamin D, mean platelet volume and platelet distribution width
Abstract
Aim: In our study, we aimed to show the relationship between ulcerative colitis activity and vitamin D, platelet distribution width, and mean platelet volume.
Material and Method: Our study was conducted at the Internal Medicine Clinic. We planned to cross-sectionally investigate the severity of ulcerative colitis activity, vitamin D level, mean platelet volume, platelet distribution width and other laboratory parameters of patients admitted to the hospital. The Truelove and Witts’ severity index was used to determine ulcerative colitis activity. In accordance with the guidelines, serum 25-OH vitamin D levels of >30 ng/ml were considered as sufficient vitamin D, 20-30 ng/ml as vitamin D insufficiency, <20 ng/ml as vitamin D deficiency, and <10 ng/ml as severe vitamin D deficiency.
Results: The study included 77 ulcerative colitis patients. Of the patients with severe ulcerative colitis activity, 10% had vitamin D deficiency and 90% had severe vitamin D deficiency (p<0.001). The patients with mild ulcerative colitis activity had the highest mean platelet volume (9.5±0.44), while the patients with severe ulcerative colitis activity had the lowest mean mean platelet volume (7.1±1.52) (p<0.001). Likewise, the patients with mild ulcerative colitis activity had the highest mean platelet distribution width (17.9±1.04), while the patients with severe ulcerative colitis activity had the lowest mean platelet distribution width (14.8±2.04) (p<0.001).
Conclusion: This study with a high level of evidence supports that 25-OH vitamin D has an anti-inflammatory effect in inflammatory diseases and that 25-OH vitamin D levels decrease as the disease activity increases. Moreover, the negative correlation between ulcerative colitis activity and mean platelet volume, platelet distribution width is demonstrated.
References
- Molodecky NA, Soon IS, Rabi DM, et al. Increasing incidence and prevalence of the inflammatory bowel diseases with time, based on systematic review. Gastroenterology 2012; 142: 46-54.
- Lewis JD, Chuai S, Nessel L, Lichtenstein GR, Aberra FN, Ellenberget JH. Use of the noninvasive components of the Mayo score to assess clinical response in ulcerative colitis. Inflamm Bowel Dis 2008; 14: 1660–6.
- Kornbluth A, Sachar DB. Ulcerative colitis practice guidelines in adult (update). Am J Gastroenterol 2004; 99: 1371-85.
- Sadeghian M, Saneei P, Siassi F, Esmaillzadeh A. Vitamin D status in relation to Crohn’s disease: a meta-analysis of observational studies. Nutrition 2016; 32: 505-14.
- Garg M, Lubel JS, Sparrow MP, Holt SG, Gibson PR. Review article: vitamin D and inflammatory bowel disease: established concepts and future directions. Aliment Pharmacol Ther 2012; 36: 324-44.
- Holick MF. McCollum award lecture, vitamin D: new horizons for the 21st century. Am J Clin Nutr 1994; 60: 619-30.
- Trang H, Cole DE, Rubin LA, Pierres A, Siu S. Evidence that VİTD3 increases serum 25 hydroxyvitamin D more efficiently than does vitamin D2. Am J Clin Nutr 1998; 68: 854-8.
- Nesby-O’Dell S, Scanlon KS, Cogswell ME, Gillespie C, Holli BW. Hypovitaminosis D prevalence and determinants among African American and white women of reproductive age. Third National Health and Nutrition Examination. Am J Clin Nutr 2002; 76: 187-92.
- Zaccardi F, Rocca B, Pitocco D, Tanese L, Rizzi A. Platelet mean volume, distribution width, and count in type 2 diabetes, impaired fasting glucose, and metabolic syndrome: a meta-analysis. Diabetes Metab Res Rev 2015; 31: 402–10.
- Akturk S, Buyukavci R. Evaluation of blood neutrophil-lymphocyte ratio and platelet distribution width as inflammatory markers in patients with fibromyalgia. Clin Rheumatol 2017; 36: 1885-89.
- Chu SG, Becker RC, Berger PB, Bhatt DL, Eikelboom JW. Mean platelet volume as a predictor of cardiovascular risk: A systematic review and meta-analysis. J Thromb Haemost 2010; 8: 148–56.
- Munger KLM, Zhang SM, O’Reilly E. Vitamin D intake and incidence of multiple sclerosis. Neurology 2004; 62: 60-5.
- Raman M, Milestone AN, Walters JR, Hart AL, Ghosh S. Vitamin D and gastrointestinal diseases: inflammatory bowel disease and colorectal cancer. Ther Adv Gastroenterol 2011; 4: 49-62.
- Travis SP, Higgins PD, Orchard T, et al. Review article: defining remission in ulcerative colitis. Aliment Pharmacol Ther 2011; 34: 113-24.
- Holick MF. Vitamin D deficiency. N Engl J Med 2007; 357: 266-81.
- Cetin M, Bakirci EM, Baysal E, Tasolar H, Balli M. Increased platelet distribution width is associated with ST-segment elevation myocardial infarction and thrombolysis failure. Angiology 2014; 65: 737-43.
- Dastjerdi MS, Emami T, Najafian A, Amini M. Mean platelet volume measurement, EDTA or citrate? Hematology 2006; 11: 317-19.
- Kowara M, Grodecki K, Huczek Z, Puchta D, Paczwa K. Platelet distribution width predicts left ventricular dysfunction in patients with acute coronary syndromes treated with percutaneous coronary intervention. Kardiol Pol 2017; 75: 42-47.
- Yang SW, Cho SH, Kwon HS, Sohn IS, Hwang HS. The significance of the platelet distribution width as a severity marker for the development of preeclampsia. Eur J Obstet Gynecol Reprod Biol 2014; 175: 107-11.
- Dinc B, Oskay A, Dinc SE, Bas B, Tekin S. New parameter in the diagnosis of acute appendicitis: platelet distribution width. World J Gastroenterol 2015; 21: 1821-26.
- Bath PM, Butterworth RJ. Platelet size: Measurement, physiology and vascular disease. Blood Coagul Fibrinolysis 1996; 7: 157-61.
- Kisacik B, Tufan A, Kalyoncu U, Karadag O, Akdogan A. Mean platelet volume (MPV) as an inflammatory marker in ankylosing spondylitis and rheumatoid arthritis. Joint Bone Spine 2008; 75: 291-94.
- Kapsoritakis AN, Koukourakis MI, Sfiridaki A, Potamianos SP, Kosmadaki MG. Mean platelet volume: A useful marker of inflammatory bowel disease activity. Am J Gastroenterol 2001; 96: 776-81.
- Jaremo P, Sandberg-Gertzen H. Platelet density and size in inflammatory bowel disease. Thromb Haemost 1996; 75: 560-61.
- Ginde AA, Mansbach JM, Camargo Jr Ca. Association between serum 25 hydroxyvitamin D level and upper respiratory tract infection in the Third National Health and Nutrition Examination Survey. Arch Intern Med 2009; 169: 384-90.
- Collins CE, Rampton DS, Rogers J, Williams NS. Platelet aggregation and neutrophil sequestration in the mesenteric circulation in inflammatory bowel disease. Eur J Gastroenterol Hepatol 1997; 9: 1213-17.
- Kapsoritakis AN, Koukourakis MI, Sfiridaki A, et al. Mean platelet volume: A useful marker of inflammatory bowel disease activity. Am J Gastroenterol 2001; 96: 776-81.
- Munger KLM, Zhang SM, O’Reilly E. Vitamin D intake and incidence of multiple sclerosis. Neurology 2004; 62: 60-5.
- Merlino LA, Curtis J, Mikuls TR. Vitamin D intake is inversely associated with rheumatoid arthritis: results from the Iowa Women’s Health Study. Arthritis Rheum 2004; 50: 72-7.
- Caraba A, Crisan V, Romosan I, Mozos I, Murariu M. Vitamin D status, disease activity, and endothelial dysfunction in early rheumatoid arthritis patients. Dis Markers 2017; 2017: e5241012.
- Carvalho JTG, Schneider M, Cuppari L. Cholecalciferol decreases inflammation and improves vitamin D regulatory enzymes in lymphocytes in the uremic environment: A randomized controlled pilot trial. PLoS One 2017; 12: e0179540.
- Hassan V, Hassan S, Seyed-Javad P. Association between serum 25 (OH) vitamin D concentrations and inflammatory bowel diseases (IBDs) activity. Med J Malaysia 2013; 68: 34–8.
- Limketkai BN, Bayless TM, Brant SR. Lower regional and temporal ultraviolet exposure is associated with increased rates and severity of inflammatory bowel disease hospitalization. Aliment Pharmacol Ther 2014; 40: 508–17.
- Dolatshahi S, Pishgar E, Jamali R. Does serum 25 hydroxyvitamin D level predict disease activity in ulcerative colitis patients? Int J Clin Lab Med 2016; 20: 10-5.
There are 34 citations in total.
Details
| Primary Language | English |
|---|---|
| Subjects | Health Care Administration |
| Journal Section | Research Articles |
| Authors | |
| Early Pub Date | October 21, 2022 |
| Publication Date | October 22, 2022 |
| Published in Issue | Year 2022 Volume: 4 Issue: 4 |
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