Research Article
ANTENATAL MAGNEZYUM SÜLFAT UYGULANMASININ PREMATÜRE MORBİDİTELERİ VE MORTALİTESİ ÜZERİNE ETKİSİNİN DEĞERLENDİRİLMESİ
Abstract
AMAÇ: Tokolitik
amaçlı kullanılan antenatal magnezyum sülfatın (MgSO4) prematüre morbidite ve
mortalitesi etkisi üzerine yapılan çalışmaların sonuçları birbirinden
farklıdır. Çalışmamızda antenatal MgSO4’e maruz kalan prematürelerin morbidite
ve mortalitesinin değerlendirilmesi amaçlanmıştır.
MATERYAL-METOT: Ocak
2013 ile Aralık 2016 tarihleri arasında yenidoğan yoğun bakım ünitemizde
izlenen, çok düşük doğum ağırlıklı (ÇDDA; 1500g) bebekler retrospektif olarak
incelendi. Prematürelerin demografik özellikleri, klinik sonuçları ve
mortalitesi kayıt edildi. Antenatal MgSO4 alan ve almayan hastalar bu
özellikler açısından karşılaştırıldı.
BULGULAR: Çalışmamıza
toplam 637 ÇDDA bebek dahil edildi. Antenatal MgSO4 uygulanma oranı %58 (n=369)
olarak tespit edildi. Antenatal MgSO4 alan grupta, solunum destek ve hastanede
yatış süresi daha uzun, hemodinamik anlamlı patent duktus arteriozus (haPDA) ve
bronkopulmoner displazi (BPD) oranı istatistiksel olarak anlamlı yüksek olarak
bulundu Antenatal MgSO4 alan ve almayan gruplar arasında demografik özellikler
ile diğer klinik sonuçlar ve mortalite açısından sonuçlar benzer bulundu
(p>0,05).
Sonuç: Antenatal
MgSO4 alan annelerin bebeklerinde özellikle haPDA, BPD sıklığı ve solunum
desteği ve yatış süresi artmış olduğu bulunmuştur. Bu nedenle antenatal MgSO4 a
maruz kalan bebeklerde bu morbiditeler açısından dikkatli olunmalıdır.
Keywords
Çok Düşük Doğum Ağırlığı Hemodinamik Anlamlı Patent Duktus Arteriozus Magnezyum Sülfat Prematüre
References
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- Referans2 Basu SK, Chickajajur V, Lopez V, Bhutada A, Pagala M, Rastogi S. Immediate clinical outcomes in preterm neonates receiving antenatal magnesium for neuroprotection. J Perinat Med 2011;40:185-9. doi: 10.1515/JPM.2011.094.
- Referans3 Paulsen ME, Dietz RM. Antenatal magnesium for preterm delivery reduces risk of cerebral palsy among surviving very preterm infants. Acta Paediatr 2018;107:175. doi:10.1111/apa.14116.
- Referans4 Garg BD. Antenatal magnesium sulfate is beneficial or harmful in very preterm and extremely preterm neonates: a new insight. J Matern Fetal Neonatal Med 2018:1-7. doi: 10.1080/14767058.2018.1424823.
- Referans5 Huusom LD, Wolf HT. Antenatal magnesium sulfate treatment for women at risk of preterm birth is safe and might decrease the risk of cerebral palsy. BMJ Evid Based Med 2018;23:195-196. doi: 10.1136/bmjebm-2018-110897.
- Referans6 Chollat C, Sentilhes L, Marret S. Fetal Neuroprotection by Magnesium Sulfate: From Translational Research to Clinical Application. Front Neurol 2018;9:247. doi: 10.3389/fneur.2018.00247.
- Referans7 Chollat C, Sentilhes L, Marret S. Protection of brain development by antenatal magnesium sulphate for infants born preterm. Dev Med Child Neurol 2018. doi: 10.1111/dmcn.14038.
- Referans8 del moral T, Gonzalez-Quintero VH, Claure N, Vanbuskirk S, Bancalari E. Antenatal exposure to magnesium sulfate and the incidence of patent ductus arteriosus in extremely low birth weight infants. J Perinatol 2007;27:154-7. doi: 10.1038/sj.jp.7211663.
- Referans9 Katayama Y, Minami H, Enomoto M, Takano T, Hayashi S, Lee YK. Antenatal magnesium sulfate and the postnatal response of the ductus arteriosus to indomethacin in extremely preterm neonates. J Perinatol 2011;31:21-4. doi: 10.1038/jp.2010.62.
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- Referans15 International Committee for the Classification of Retinopathy of Prematurity. The International Classification of Retinopathy of Prematurity revisited. Arch Ophthalmol 2005; 123:991-999. doi: 10.1001/archopht.123.7.991.
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- Referans19 Nakanishi T, Gu H, Hagiwara N, Momma K. Mechanisms of oxygen-induced contraction of ductus arteriosus isolated from the fetal rabbit. Circ Res 1993;72:1218-28.
- Referans20 Kamitomo M, Sameshima H, Ikenoue T, Nishibatake M. Fetal cardiovascular function during prolonged magnesium sulfate tocolysis. J Perinat Med 2000;28:377-82. doi: 10.1515/JPM.2000.048.
- Referans21 Satake K, Lee JD, Shimizu H, Uzui H, Mitsuke Y, Yue H, et al. Effects of magnesium on prostacyclin synthesis and intracellular free calcium concentration in vascular cells. Magnes Res 2004;17:20-7.
- Referans22 Tolsa JF, Gao Y, Raj JU. Developmental change in magnesium sulfate-induced relaxation of rabbit pulmonary arteries. J Appl Physiol (1985). 1999;87:1589-94.
Year 2018,
Volume: 51 Issue: 3, 215 - 218, 26.12.2018
Abstract
References
- Referans1 Klauser CK, Briery CM, Keiser SD, Martin RW, Kosek MA, Morrison JC. Effect of antenatal tocolysis on neonatal outcomes. J Matern Fetal Neonatal Med 2012;25:2778-81. doi: 10.3109/14767058.2012.714819.
- Referans2 Basu SK, Chickajajur V, Lopez V, Bhutada A, Pagala M, Rastogi S. Immediate clinical outcomes in preterm neonates receiving antenatal magnesium for neuroprotection. J Perinat Med 2011;40:185-9. doi: 10.1515/JPM.2011.094.
- Referans3 Paulsen ME, Dietz RM. Antenatal magnesium for preterm delivery reduces risk of cerebral palsy among surviving very preterm infants. Acta Paediatr 2018;107:175. doi:10.1111/apa.14116.
- Referans4 Garg BD. Antenatal magnesium sulfate is beneficial or harmful in very preterm and extremely preterm neonates: a new insight. J Matern Fetal Neonatal Med 2018:1-7. doi: 10.1080/14767058.2018.1424823.
- Referans5 Huusom LD, Wolf HT. Antenatal magnesium sulfate treatment for women at risk of preterm birth is safe and might decrease the risk of cerebral palsy. BMJ Evid Based Med 2018;23:195-196. doi: 10.1136/bmjebm-2018-110897.
- Referans6 Chollat C, Sentilhes L, Marret S. Fetal Neuroprotection by Magnesium Sulfate: From Translational Research to Clinical Application. Front Neurol 2018;9:247. doi: 10.3389/fneur.2018.00247.
- Referans7 Chollat C, Sentilhes L, Marret S. Protection of brain development by antenatal magnesium sulphate for infants born preterm. Dev Med Child Neurol 2018. doi: 10.1111/dmcn.14038.
- Referans8 del moral T, Gonzalez-Quintero VH, Claure N, Vanbuskirk S, Bancalari E. Antenatal exposure to magnesium sulfate and the incidence of patent ductus arteriosus in extremely low birth weight infants. J Perinatol 2007;27:154-7. doi: 10.1038/sj.jp.7211663.
- Referans9 Katayama Y, Minami H, Enomoto M, Takano T, Hayashi S, Lee YK. Antenatal magnesium sulfate and the postnatal response of the ductus arteriosus to indomethacin in extremely preterm neonates. J Perinatol 2011;31:21-4. doi: 10.1038/jp.2010.62.
- Referans10 Elimian A, Verma R, Ogburn P, Wiencek V, Spitzer A, Quirk JG. Magnesium sulfate and neonatal outcomes of preterm neonates. J Matern Fetal Neonatal Med 2002;12:118-22. doi: 10.1080/jmf.12.2.118.122.
- Referans11 Diguisto C, Foix L'Helias L, Morgan AS, Ancel PY, Kayem G, Kaminski M, et al. Neonatal Outcomes in Extremely Preterm Newborns Admitted to Intensive Care after No Active Antenatal Management: A Population-Based Cohort Study. J Pediatr 2018. pii: S0022-3476(18)31049-7. doi: 10.1016/j.jpeds.2018.07.072.
- Referans12 Dargaville PA, Gerber A, Johansson S, De Paoli AG, Kamlin CO, Orsini F, et al. Incidence and Outcome of CPAP Failure in Preterm Infants. Pediatrics 2016; 138(1). pii: e20153985. doi: 10.1542/peds.2015-3985.
- Referans13 Leal YA, Álvarez-Nemegyei J, Lavadores-May AI, Girón-Carrillo JL, Cedillo-Rivera R, Velazquez JR. Cytokine profile as diagnostic and prognostic factor in neonatal sepsis. J Matern Fetal Neonatal Med 2018: 1-7. doi: 10.1080/14767058.2018.1449828.
- Referans14 Walsh MC, Wilson-Costello D, Zadell A, Newman N, Fanaroff A. Safety, reliability, and validity of a physiologic definition of bronchopulmonary dysplasia. J Perinatol 2003; 23: 451-6. doi: 10.1038/sj.jp.7210963.
- Referans15 International Committee for the Classification of Retinopathy of Prematurity. The International Classification of Retinopathy of Prematurity revisited. Arch Ophthalmol 2005; 123:991-999. doi: 10.1001/archopht.123.7.991.
- Referans16 Papile LA, Burstein J, Burstein R, Koffler H. Incidence and evolution of subependymal and intraventricular hemorrhage: a study of infants with birth weights less than 1,500 gm. J Pediatr 1978;92:529-34. Referans17 Bell MJ, Ternberg JL, Feigin RD, Keating JP, Marshall R, Barton L, et al. Neonatal necrotizing enterocolitis. Therapeutic decision based upon clinical staging. An Surg 1978;187:1-7.
- Referans18 Oncel MY, Yurttutan S, Erdeve O, Uras N, Altug N, Oguz SS, et al. Oral paracetamol versus oral ibuprofen in the management of patent ductus arteriosus in preterm infants: a randomized controlled trial. J Pediatr 2014;164:510-4.e1. doi: 10.1016/j.jpeds.2013.11.008.
- Referans19 Nakanishi T, Gu H, Hagiwara N, Momma K. Mechanisms of oxygen-induced contraction of ductus arteriosus isolated from the fetal rabbit. Circ Res 1993;72:1218-28.
- Referans20 Kamitomo M, Sameshima H, Ikenoue T, Nishibatake M. Fetal cardiovascular function during prolonged magnesium sulfate tocolysis. J Perinat Med 2000;28:377-82. doi: 10.1515/JPM.2000.048.
- Referans21 Satake K, Lee JD, Shimizu H, Uzui H, Mitsuke Y, Yue H, et al. Effects of magnesium on prostacyclin synthesis and intracellular free calcium concentration in vascular cells. Magnes Res 2004;17:20-7.
- Referans22 Tolsa JF, Gao Y, Raj JU. Developmental change in magnesium sulfate-induced relaxation of rabbit pulmonary arteries. J Appl Physiol (1985). 1999;87:1589-94.
There are 21 citations in total.
Details
| Primary Language | Turkish |
|---|---|
| Journal Section | Original research article |
| Authors | |
| Publication Date | December 26, 2018 |
| Submission Date | November 10, 2018 |
| Published in Issue | Year 2018 Volume: 51 Issue: 3 |