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Nörofibromatozis Tip1 Hastalarında Telomeraz Aktivitesi

Year 2018, Volume: 27 Issue: 2, 199 - 205, 30.06.2018
https://doi.org/10.17827/aktd.365700

Abstract

Çeşitli kanser türlerinde yapılan çalışmalarda kısa telomer uzunluğu ve düşük telomeraz aktivitesinin bazı kanser tiplerinde koruyucu etkisi olduğundan bahsedilmektedir. Nörofibromatozis Tip-1 (NF1) hastalarının bazı kanser türleri için yüksek risk altında olduğu bilinmektedir. Beyin tümörleri, malign periferik sinir kılıfı tümörleri, optik gliom, yumuşak doku sarkomları gibi malign tümörler ve nörofibromlar ve hamartomlar gibi benign olanlar bunlar arasında sayılabilir. İlginç olarak NF1 hastalarında ortaya çıkan kanserlerde prognoz genel olarak aynı tanılı NF1 olmayan hastalara göre daha iyi olmakta ve sağkalım daha uzun olmaktadır. Bu derlemede NF1 hastalarındaki telomeraz aktivitesinin gelişebilecek kanserlerle olan ilişkisi literatür bilgileri ışığında irdelenmiştir. NF1 hastalarında benign veya malign tümör gelişimi açısından telomeraz aktivitesi ölçümü tümör belirleyici işlevi görebilir.

References

  • 1. Dahse R, Fiedier W, Ernst G. Telomeres and telomerase: biological and clinical importance. Clin Chem 1997;43: 708-714.
  • 2. Rhyu M. Telomeres, telomerase, and immortality. J Natl Cancer Inst 1995;87: 884-894.
  • 3. Feng J, Funk WD, Wang S, Weinrich S, Avilion A, Chiu C, et al. The RNA component of human telomerase. Science 1995;269: 1236-1241.
  • 4. Harrington L, McPhail T, Mar V, Zhou W, Oulton R, Program AE, et al. A mammalian telomerase-associated protein. Science 1997;275: 973-977.
  • 5. Nakamura TM, Morin GB, Chapman KB, Weinrich SL, Andrews WH; Lıngner J, Harley CB, Cech TR. Telomerase catalytic subunit homolog from fission yeast and human. Science 1997;277: 955-959.
  • 6. Mantripragada KK, Caley M, Stephens P, Jones CJ, Kluwe L, Guha A, Mautner V, Upadhyaya M. Telomerase activity is a biomarker for high grade malignant peripheral nerve sheath tumors in neurofibromatosis type 1 individuals. Genes Chromosomes Cancer. 2008;47: 238-246.
  • 7. Shay JW, Bacchetti S. A survey of telomerase activity in human cancer. Eur J Cancer 1997;33: 787–791.
  • 8. Kim NW, Piatyszek MA, Prowse KR, Harley CB, West MD, Ho PL, Coviello GM, Wright WE, Weinrich SL, Shay JW. Specific association of human telomerase activity with immortal cells and cancer. Science 1994;266: 2011–2015.
  • 9. Greider CW. Telomerase activity, cell proliferation, and cancer. Proc Natl Acad Sci USA 1998;95: 90–92.
  • 10. Blackburn EH. Structure and function of telomeres. Nature. 1991;350: 569–573.
  • 11. Hiyama K, Hirai Y, Kyoizumi S, Akiyama M, Hiyama E, Piatyszek MA, Shay JW, Ishioka S, Yamakido M. Activation of telomerase in human lymphocytes and hematopoietic progenitor cells. J Immunol. 1995;155:3711–3715.
  • 12. Ge P, Zhang B, Zhang J, Gao Z, He W. Telomerase activity of peripheral blood mononuclear cells from patients with laryngeal carcinoma. Am J Clin Oncol. 2004;27: 191-194.
  • 13. Meeker AK, Coffey DS. Telomerase: a promising marker of biological immortality of germ, stem, and cancer cells. A review. Biochemistry (Mosc) 1997;62: 1323-1331.
  • 14. Weischer M, nordestgaard BG, Cawthon RM, et al. Short telomere length, cancer sur-vival, and cancer risk in 47102 individuals. J Natl Cancer Inst. 2013;105: 459–468.
  • 15. Wentzensen IM, Mirabello L, Pfeiffer RM, et al. The association of telomere length and cancer: a meta-analysis. Cancer Epidemiol Biomarkers Prev. 2011;20: 1238–1250.
  • 16. İncecik F, Altunbaşak Ş, Hergüner MÖ, Bayram İ, Küpeli S, Demirbilek H. Oncologic manifestations in children with neurofibromatosis type 1 in Turkey. Turk J Pediatr. 2013;55:266-270.
  • 17. Gül I, Dündar O, Bodur S, Tunca Y, Tütüncü L. The status of telomerase enzyme activity in benign and malignant gynaecologic pathologies. Balkan Med J. 2013;30:287-292.
  • 18. Liu Y, Snow BE, Hande MP, Yeung D, Erdmann NJ, Wakeham A, Itie A, Siderovski DP, Lansdorp PM, Robinson MO, Harrington L. The telomerase reverse transcriptase is limiting and necessary for telomerase function in vivo. Curr Biol 2000;10: 1459–1462.
  • 19. Tomoda R, Seto M, Tsumuki H, Iida K, Yamazaki T, Sonoda J, Matsumine A, Uchida A. Telomerase activity and human telomerase reverse transcriptase mRNA expression are correlated with clinical aggressiveness in soft tissue tumors. Cancer 2002;95: 1127–1133.
  • 20. Levy P, Vidaud D, Leroy K, Laurendeau I, Wechsler J, Bolasco G, Parfait B, Wolkenstein P, Vidaud M, Bieche I. Molecular profiling of malignant peripheral nerve sheath tumors associated with neurofibromatosis type 1, based on large-scale real-time RTPCR. Mol Cancer 2004;3: 20.
  • 21. Lee BJ, Wang SG, Choi JS, Lee JC, Goh EK, Kim MG. The prognostic value of telomerase expression in peripheral blood mononuclear cells of head and neck cancer patients. Am J Clin Oncol 2006; 29: 163-167.

Telomerase Activity in Patients with Neurofibromatosis Type 1

Year 2018, Volume: 27 Issue: 2, 199 - 205, 30.06.2018
https://doi.org/10.17827/aktd.365700

Abstract

In various studies short telomere length and low telomerase activity have been shown to have a protective role in some types of cancer. Patients with NF1 are under risk of developing certain types of cancer. Malignant tumors such as brain tumors, malignant peripheral nerve sheat tumors, optic gliomas, soft tissue sarcomas and benign tumors such as neurofibromas and hamartomas are among them. Interestingly, prognosis is generally better in patients with NF1 than those without NF1. In the present review, we aimed to delineate telomerase activity in patients with NF1 with various types of cancer. Measurement of telomerase activity in patients with NF1 can be a diagnostic marker for tumorigenesis.

References

  • 1. Dahse R, Fiedier W, Ernst G. Telomeres and telomerase: biological and clinical importance. Clin Chem 1997;43: 708-714.
  • 2. Rhyu M. Telomeres, telomerase, and immortality. J Natl Cancer Inst 1995;87: 884-894.
  • 3. Feng J, Funk WD, Wang S, Weinrich S, Avilion A, Chiu C, et al. The RNA component of human telomerase. Science 1995;269: 1236-1241.
  • 4. Harrington L, McPhail T, Mar V, Zhou W, Oulton R, Program AE, et al. A mammalian telomerase-associated protein. Science 1997;275: 973-977.
  • 5. Nakamura TM, Morin GB, Chapman KB, Weinrich SL, Andrews WH; Lıngner J, Harley CB, Cech TR. Telomerase catalytic subunit homolog from fission yeast and human. Science 1997;277: 955-959.
  • 6. Mantripragada KK, Caley M, Stephens P, Jones CJ, Kluwe L, Guha A, Mautner V, Upadhyaya M. Telomerase activity is a biomarker for high grade malignant peripheral nerve sheath tumors in neurofibromatosis type 1 individuals. Genes Chromosomes Cancer. 2008;47: 238-246.
  • 7. Shay JW, Bacchetti S. A survey of telomerase activity in human cancer. Eur J Cancer 1997;33: 787–791.
  • 8. Kim NW, Piatyszek MA, Prowse KR, Harley CB, West MD, Ho PL, Coviello GM, Wright WE, Weinrich SL, Shay JW. Specific association of human telomerase activity with immortal cells and cancer. Science 1994;266: 2011–2015.
  • 9. Greider CW. Telomerase activity, cell proliferation, and cancer. Proc Natl Acad Sci USA 1998;95: 90–92.
  • 10. Blackburn EH. Structure and function of telomeres. Nature. 1991;350: 569–573.
  • 11. Hiyama K, Hirai Y, Kyoizumi S, Akiyama M, Hiyama E, Piatyszek MA, Shay JW, Ishioka S, Yamakido M. Activation of telomerase in human lymphocytes and hematopoietic progenitor cells. J Immunol. 1995;155:3711–3715.
  • 12. Ge P, Zhang B, Zhang J, Gao Z, He W. Telomerase activity of peripheral blood mononuclear cells from patients with laryngeal carcinoma. Am J Clin Oncol. 2004;27: 191-194.
  • 13. Meeker AK, Coffey DS. Telomerase: a promising marker of biological immortality of germ, stem, and cancer cells. A review. Biochemistry (Mosc) 1997;62: 1323-1331.
  • 14. Weischer M, nordestgaard BG, Cawthon RM, et al. Short telomere length, cancer sur-vival, and cancer risk in 47102 individuals. J Natl Cancer Inst. 2013;105: 459–468.
  • 15. Wentzensen IM, Mirabello L, Pfeiffer RM, et al. The association of telomere length and cancer: a meta-analysis. Cancer Epidemiol Biomarkers Prev. 2011;20: 1238–1250.
  • 16. İncecik F, Altunbaşak Ş, Hergüner MÖ, Bayram İ, Küpeli S, Demirbilek H. Oncologic manifestations in children with neurofibromatosis type 1 in Turkey. Turk J Pediatr. 2013;55:266-270.
  • 17. Gül I, Dündar O, Bodur S, Tunca Y, Tütüncü L. The status of telomerase enzyme activity in benign and malignant gynaecologic pathologies. Balkan Med J. 2013;30:287-292.
  • 18. Liu Y, Snow BE, Hande MP, Yeung D, Erdmann NJ, Wakeham A, Itie A, Siderovski DP, Lansdorp PM, Robinson MO, Harrington L. The telomerase reverse transcriptase is limiting and necessary for telomerase function in vivo. Curr Biol 2000;10: 1459–1462.
  • 19. Tomoda R, Seto M, Tsumuki H, Iida K, Yamazaki T, Sonoda J, Matsumine A, Uchida A. Telomerase activity and human telomerase reverse transcriptase mRNA expression are correlated with clinical aggressiveness in soft tissue tumors. Cancer 2002;95: 1127–1133.
  • 20. Levy P, Vidaud D, Leroy K, Laurendeau I, Wechsler J, Bolasco G, Parfait B, Wolkenstein P, Vidaud M, Bieche I. Molecular profiling of malignant peripheral nerve sheath tumors associated with neurofibromatosis type 1, based on large-scale real-time RTPCR. Mol Cancer 2004;3: 20.
  • 21. Lee BJ, Wang SG, Choi JS, Lee JC, Goh EK, Kim MG. The prognostic value of telomerase expression in peripheral blood mononuclear cells of head and neck cancer patients. Am J Clin Oncol 2006; 29: 163-167.
There are 21 citations in total.

Details

Primary Language Turkish
Subjects Health Care Administration
Journal Section Review
Authors

Serhan Küpeli 0000-0001-7271-1803

Publication Date June 30, 2018
Acceptance Date December 18, 2017
Published in Issue Year 2018 Volume: 27 Issue: 2

Cite

AMA Küpeli S. Nörofibromatozis Tip1 Hastalarında Telomeraz Aktivitesi. aktd. June 2018;27(2):199-205. doi:10.17827/aktd.365700