ATTENTION PLEASE!!! POSSIBLE RISK OF STROKE IN THE USE OF SILDENAFIL IN PEOPLE WITH COMORBIDITY OR BEHÇET DISEASE: A CASE REPORT
Abstract
Sildenafil is one of the most commonly prescribed drugs for male erectile function. Transient ischemic attack (TIA) and ischemic/hemorrhagic stroke cases with sexual activity have been reported after sildenafil intake. Here, we describe an ischemic cerebrovascular disease case with a history of hypertension (HT), diabetes mellitus (DM), Behçet's disease (BD) and who applied to the emergency department with the development of sudden vision loss after sildenafil use. The common use of sildenafil, especially in patients with comorbidities, should be kept in mind as it can lead to serious side effects. In patients with a history of cerebrovascular disease, questioning the use of the medication is crucial.
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References
- Stefanović-Budimkić M, Jovanović DR, Beslać-Bumbaširević L, Ercegovac MD. Recurrent ischemic stroke associated with sildenafil and tadalafil use in a young adult. Clin Neurol Neurosurg. 2012 May;114 (4):405-7. doi: 10.1016/j.clineuro.2011.11.003.
- Byoun HS, Lee YJ, Yi HJ. Subarachnoid Hemorrhage and Intracerebral Hematoma due to Sildenafil Ingestion in a Young Adult. J Korean Neurosurg Soc. 2010 Mar;47 (3):210-2. doi: 10.3340/jkns.2010.47.3.210.
- Kloner RA. Sex and the patient with cardiovascular risk factors: focus on sildenafil. Am J Med. 2000 Dec 18;109 Suppl 9A:13S-21S; discussion 29S-30S. doi: 10.1016/s0002-9343(00)00656-2.
- Kim KK, Kim DG, Ku YH, Lee YJ, Kim WC, Kim OJ, Kim HS. Bilateral cerebral hemispheric infarction associated with sildenafil citrate (Viagra) use. Eur J Neurol. 2008 Mar;15(3):306-8. doi: 10.1111/j.1468-1331.2007.02025.x. PMID: 18290852.
- September 27 Highlight and Commentary: Effect of sildenafil (Viagra) on cerebral blood vessels Neurology 2005;65;785 DOI 10.1212/01.wnl.0000182169.91597.6c
- Finsterer J. Transient global amnesia associated with sildenafil use. Report of one case. Rev Med Chil. 2019 Apr;147(4):527-529. doi: 10.4067/S0034-98872019000400527.
- Carter JE. Anterior ischemic optic neuropathy and stroke with use of PDE-5 inhibitors for erectile dysfunction: cause or coincidence? J Neurol Sci. 2007 Nov 15;262 (1-2):89-97. doi: 10.1016/j.jns.2007.06.018. Hayashi K, Minezaki KK, Narukawa M, Ookubo M, Mitsuhashi T, Shimada K. Atrial fibrillation and continuous hypotension induced by sildenafil in an intermittent WPW syndrome patient. Jpn Heart J. 1999; 40:827-830.
- Akman-Demir G, Serdaroğlu P, Taşçı B. Behçet hastalığında nörolojik tutulumun klinik paternleri: 200 hastanın değerlendirilmesi. Nöro-Behçet Çalışma Grubu Beyin. (1999) 122 (Sayfa 11): 2171–82. 10.1093 / brain / 122.11.2171
- Cetin M, Ozturk U, Cakici M, Yildiz E. Acute inferior myocardial infarction in a young male patient associated with Behcet’s disease and sildenafil. BMJ Case Rep. 2014 Jan 21;2014:bcr2013201189. doi: 10.1136/bcr-2013-201189.
Lütfen Dikkat!!! Komorbidite Ve/Veya Behçet Hastaliği Olan Kişilerde Sildenafil Kullaniminda Olasi İnme Riski: Olgu Sunumu
Abstract
Sildenafil erkek ereksiyon işlevi için en sık reçete edilen ilaçlardandır.Sildenafil alımı sonrasında cinsel aktivite ile birlikte geçici iskemik atak (GİA), iskemik/hemorajik inme olguları bildirilmiştir. Burada özgeçmişinde hipertansiyon (HT), diyabet (DM), Behçet hastalığı (BH) bulunan ve sildenafil kullanımı sonrasında ani görme kaybı gelişmesiyle acil servise başvuran bir iskemik serebrovasküler hastalık olgusu anlatılmaktadır. Sildenafil kullanımının yaygın olması ve özellikle komorbiditesi olan hastalarda ciddi yan etkilere sebep olabileceği akılda tutulmalıdır. Serebrovasküler hastalık öyküsü ile gelen hastalarda ilaç kullanımının sorgulanması oldukça önemlidir.
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Thanks
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References
- Stefanović-Budimkić M, Jovanović DR, Beslać-Bumbaširević L, Ercegovac MD. Recurrent ischemic stroke associated with sildenafil and tadalafil use in a young adult. Clin Neurol Neurosurg. 2012 May;114 (4):405-7. doi: 10.1016/j.clineuro.2011.11.003.
- Byoun HS, Lee YJ, Yi HJ. Subarachnoid Hemorrhage and Intracerebral Hematoma due to Sildenafil Ingestion in a Young Adult. J Korean Neurosurg Soc. 2010 Mar;47 (3):210-2. doi: 10.3340/jkns.2010.47.3.210.
- Kloner RA. Sex and the patient with cardiovascular risk factors: focus on sildenafil. Am J Med. 2000 Dec 18;109 Suppl 9A:13S-21S; discussion 29S-30S. doi: 10.1016/s0002-9343(00)00656-2.
- Kim KK, Kim DG, Ku YH, Lee YJ, Kim WC, Kim OJ, Kim HS. Bilateral cerebral hemispheric infarction associated with sildenafil citrate (Viagra) use. Eur J Neurol. 2008 Mar;15(3):306-8. doi: 10.1111/j.1468-1331.2007.02025.x. PMID: 18290852.
- September 27 Highlight and Commentary: Effect of sildenafil (Viagra) on cerebral blood vessels Neurology 2005;65;785 DOI 10.1212/01.wnl.0000182169.91597.6c
- Finsterer J. Transient global amnesia associated with sildenafil use. Report of one case. Rev Med Chil. 2019 Apr;147(4):527-529. doi: 10.4067/S0034-98872019000400527.
- Carter JE. Anterior ischemic optic neuropathy and stroke with use of PDE-5 inhibitors for erectile dysfunction: cause or coincidence? J Neurol Sci. 2007 Nov 15;262 (1-2):89-97. doi: 10.1016/j.jns.2007.06.018. Hayashi K, Minezaki KK, Narukawa M, Ookubo M, Mitsuhashi T, Shimada K. Atrial fibrillation and continuous hypotension induced by sildenafil in an intermittent WPW syndrome patient. Jpn Heart J. 1999; 40:827-830.
- Akman-Demir G, Serdaroğlu P, Taşçı B. Behçet hastalığında nörolojik tutulumun klinik paternleri: 200 hastanın değerlendirilmesi. Nöro-Behçet Çalışma Grubu Beyin. (1999) 122 (Sayfa 11): 2171–82. 10.1093 / brain / 122.11.2171
- Cetin M, Ozturk U, Cakici M, Yildiz E. Acute inferior myocardial infarction in a young male patient associated with Behcet’s disease and sildenafil. BMJ Case Rep. 2014 Jan 21;2014:bcr2013201189. doi: 10.1136/bcr-2013-201189.
Details
| Primary Language | English |
|---|---|
| Subjects | Clinical Sciences (Other) |
| Journal Section | Case Reports |
| Authors | |
| Project Number | . |
| Early Pub Date | December 28, 2023 |
| Publication Date | February 7, 2024 |
| Submission Date | November 22, 2023 |
| Acceptance Date | December 6, 2023 |
| Published in Issue | Year 2024 Volume: 4 Issue: 9 |
