Yenidoğan menenjitinde eş zamanlı alınan beyin omurilik sıvısı ve kan kültür sonuçlarının değerlendirilmesi
Abstract
Amaç: Bu çalışmanın amacı, yenidoğan yoğun bakım ünitesinde hem kan hem de beyin omurilik sıvısı kültürlerinin eşzamanlı bulgularını araştırmak ve yeni doğan sepsis ve menenjitten sorumlu olan etiyolojik patojenleri saptamatır.
Gereç ve Yöntem: Bu çalışma Kasım 2013 - Ekim 2015 tarihleri arasında yenidoğan bölümümüzde yapıldı. Bu dönemde neonatal sepsis belirtileri ve semptomları olan 732 yenidoğan çalışmaya dahil edildi. Çalışmaya uygun olan hastalardan eş zamanlı kan ve beyin omurilik sıvısı kültürleri alınarak sepsis ve menenjit çalışması yapıldı.
Bulgular: Yüz vakada (%13,7) beyin omurilik sıvısı kültürü pozitifti. Menenjit tanılı 59 yanidoğan hastasında kan kültürü pozitif olarak bulundu. Stafilokok bakterisi (%48) menejitten sorumlu en sık görülen organizmaydı ve bunu klebsilla (%19) ve psodomonas (%10) izledi. Kan kültüründen eş zamanlı olarak izole edilen bakteriler ise stafilokok (%24) , kelbsiella (%13) ve psodomonastı (%8).
Sonuç: Çalışmamızda, ünitemizde neonatal sepsis ve menenjitten sorumlu olan ana etiyolojik ajanlar stafilokok, klebsiella ve psödomonas idi.
References
- 1. Ku LC, Bogges KA, Cohen-Wolkowiez M. Bacterial meningitis in the infant. Clin Perinatol. 2015;42:29-45.
- 2. Heath PT, Okike IO, Oeser C. Neonatal meningitis: can we do better? Adv Exp Med Biol. 2011;719:11–24.
- 3. Shane AL, Stoll BJ. Recent developments and current issues in the epidemiology, diagnosis, and management of bacterial and fungal neonatal sepsis. Am J Perinatol. 2013;30:131–41.
- 4. Fanaroff AA, Korones SB, Wright LL, Verter J, Poland RL, Bauer CR et al. Incidence, presenting features, risk factors and significance of late onset septicemia in very low birth weight infants. The National Institute of Child Health and Human Development Neonatal Research Network. Pediatr Infect Dis J. 1998;17:593–8.
- 5. Furyk JS, Swann O, Molyneux E. Systematic review: neonatal meningitis in the developing world. Trop Med Int Health. 2011;16:672–9.
- 6. Heath PT, Okike IO. Neonatal bacterial meningitis: an update. Paediatrics Child Health. 2010;20:526–530.
- 7. Thaver D, Zaidi AK. Burden of neonatal infections in developing countries: a review of evidence from community-based studies. Pediatr Infect Dis J. 2009;28:3–9.
- 8. Stoll BJ, Hansen N, Fanaroff AA et al. Late-onset sepsis in very low birth weight neonates: the experience of the NICHD Neonatal Research Network. Pediatrics. 2002;110:285–91.
- 9. Cohen-Wolkowiez M, Moran C, Benjamin DK et al. Early and late onset sepsis in late preterm infants. Pediatr Infect Dis J. 2009;28:1052–6.
- 10. Gaschignard J, Levy C, Romain O et al. Neonatal Bacterial Meningitis, 444 Cases in 7 Years. Pediatr Infect Dis J. 2011;30:212–7.
- 11. Fluegge K, Siedler A, Heinrich B et al. Incidence and clinical presentation of invasive neonatal group B streptococcal infections in Germany. Pediatrics. 2006;117:e1139–45. 12. Ansong AK, Smith PB, Benjamin DK et al. Group B streptococcal meningitis: cerebrospinal fluid parameters in the era of intrapartum antibiotic prophylaxis. Early Hum Dev. 2009;85:5–7.
- 13. Edwards, M. Postnatal bacterial infections. In: Martin, RJ.; Fanaroff, AA.; Walsh, MC., editors. Fanaroff and Martin's neonatal-perinatal medicine: diseases of the fetus and infant. 9th edition. Philadelphia: Saunders/Elsevier. 2011;793-830.
- 14. Carr JP, Burgner DP, Hardikar RS, Buttery JP. Empiric antibiotic regimens for neonatal sepsis in Australian and New Zealand neonatal intensive care units. J Paediatr Child Health. 2017;53:680-4.
- 15. Softić I, Tahirović H, Hasanhodžić M. Neonatal bacterial meningitis: Results from a cross-sectional hospital based study. Acta Med Acad. 2015;44:117-23.
- 16. Camacho-Gonzalez A, Spearman PW, Stoll BJ. Neonatal infectious diseases: evaluation of neonatal sepsis. Pediatr Clin North Am. 2013;60:367–89.
- 17. Gitto E, Karbownik M, Reiter RJ et al. Effects of melatonin treatment in septic newborns. Pediatr Res. 2001;50:756-60.
Abstract
Purpose: The aim of our present study was to investigate the simultaneous findings of both blood and cerebrospinal fluid cultures and to determine the etiological pathogens responsible for neonatal sepsis and meningitis in our neonatal intensive care unit.
Materials and Methods: This study was carried out in our newborn department from November 2013 to October 2015. During this period 732 neonates with signs and symptoms of neonatal sepsis were included in our study. Sepsis and meningitis work up were performed and simultaneous blood and cerebrospinal fluid cultures were taken from eligible patients.
Results: Cerebrospinal fluid cultures were positive in100 (13.7%) of cases. Positive blood cultures were found in 59 (8.1%) neonates with meningitis. Staphylococcus bacteria (48%) was the most frequent organism responsible for confirmed meningitis, followed by klebsiella (19%) and pseudomonas (10%). Simultaneous pathogens isolated from blood cultures were Staphylococcus (%24), klebsiella (13%) and pseudomonas (8%).
Conclusion: In our study group staphylococcus, klebsiella and pseudomonas were the main etiological agents that were responsible for neonatal sepsis and meningitis in our unit.
References
- 1. Ku LC, Bogges KA, Cohen-Wolkowiez M. Bacterial meningitis in the infant. Clin Perinatol. 2015;42:29-45.
- 2. Heath PT, Okike IO, Oeser C. Neonatal meningitis: can we do better? Adv Exp Med Biol. 2011;719:11–24.
- 3. Shane AL, Stoll BJ. Recent developments and current issues in the epidemiology, diagnosis, and management of bacterial and fungal neonatal sepsis. Am J Perinatol. 2013;30:131–41.
- 4. Fanaroff AA, Korones SB, Wright LL, Verter J, Poland RL, Bauer CR et al. Incidence, presenting features, risk factors and significance of late onset septicemia in very low birth weight infants. The National Institute of Child Health and Human Development Neonatal Research Network. Pediatr Infect Dis J. 1998;17:593–8.
- 5. Furyk JS, Swann O, Molyneux E. Systematic review: neonatal meningitis in the developing world. Trop Med Int Health. 2011;16:672–9.
- 6. Heath PT, Okike IO. Neonatal bacterial meningitis: an update. Paediatrics Child Health. 2010;20:526–530.
- 7. Thaver D, Zaidi AK. Burden of neonatal infections in developing countries: a review of evidence from community-based studies. Pediatr Infect Dis J. 2009;28:3–9.
- 8. Stoll BJ, Hansen N, Fanaroff AA et al. Late-onset sepsis in very low birth weight neonates: the experience of the NICHD Neonatal Research Network. Pediatrics. 2002;110:285–91.
- 9. Cohen-Wolkowiez M, Moran C, Benjamin DK et al. Early and late onset sepsis in late preterm infants. Pediatr Infect Dis J. 2009;28:1052–6.
- 10. Gaschignard J, Levy C, Romain O et al. Neonatal Bacterial Meningitis, 444 Cases in 7 Years. Pediatr Infect Dis J. 2011;30:212–7.
- 11. Fluegge K, Siedler A, Heinrich B et al. Incidence and clinical presentation of invasive neonatal group B streptococcal infections in Germany. Pediatrics. 2006;117:e1139–45. 12. Ansong AK, Smith PB, Benjamin DK et al. Group B streptococcal meningitis: cerebrospinal fluid parameters in the era of intrapartum antibiotic prophylaxis. Early Hum Dev. 2009;85:5–7.
- 13. Edwards, M. Postnatal bacterial infections. In: Martin, RJ.; Fanaroff, AA.; Walsh, MC., editors. Fanaroff and Martin's neonatal-perinatal medicine: diseases of the fetus and infant. 9th edition. Philadelphia: Saunders/Elsevier. 2011;793-830.
- 14. Carr JP, Burgner DP, Hardikar RS, Buttery JP. Empiric antibiotic regimens for neonatal sepsis in Australian and New Zealand neonatal intensive care units. J Paediatr Child Health. 2017;53:680-4.
- 15. Softić I, Tahirović H, Hasanhodžić M. Neonatal bacterial meningitis: Results from a cross-sectional hospital based study. Acta Med Acad. 2015;44:117-23.
- 16. Camacho-Gonzalez A, Spearman PW, Stoll BJ. Neonatal infectious diseases: evaluation of neonatal sepsis. Pediatr Clin North Am. 2013;60:367–89.
- 17. Gitto E, Karbownik M, Reiter RJ et al. Effects of melatonin treatment in septic newborns. Pediatr Res. 2001;50:756-60.
Details
| Primary Language | English |
|---|---|
| Subjects | Health Care Administration |
| Journal Section | Research |
| Authors | |
| Publication Date | September 30, 2019 |
| Acceptance Date | January 6, 2019 |
| Published in Issue | Year 2019 Volume: 44 Issue: 3 |
