Abstract
Amaç: Çalışmamızın amacı, acil servise ilaç intoksikasyonu olarak başvuran ve
sonrasında İç Hastalıkları servisinde takip ve tedavi edilen hastaların,
demografik özellikleri, intoksikasyon için aldıkları ilaçlar ve prognozları
açısından değerlendirmeyi amaçladık.
Gereç
ve Yöntem: Çalışmaya
2013-2018 yılları arasında, ilaç intoksikasyonu nedeni ile İç Hastalıkları
servisinde takip ve tedavi edilen 248 hasta alınmıştır. Hastalar, cinsiyet ve
yaş özellikleri, psikiyatrik ilaç kullanım öyküleri, öğrenim durumları,
intoksikasyon için aldıkları ilaçların niteliği, aldığı ilaçların grup
sayıları, prognozları ve hastanede yatış süreleri açısından değerlendirildi.
Bulgular: Çalışmaya İç Hastalıkları
servisinde ilaç intoksikasyonu olarak takip ve tedavi edilen 248 hasta dahil
edilmiştir. Bu hastaların 161 (%64,9)’i kadın, 87 (%35,1)’si erkek hastalardı.
Yaş ortalamaları kadın hastalarda 27,8±14,7 (18-64) yıl, erkek hastalarda 24,2±13,8
(18-53) yıldı. Kadın hastaların 108 (%43,5) tanesi bekar iken, erkek hastaların
64 (%25,8) tanesi bekardı. Kadın hastaların 91 (%36,6)’inde özgeçmişlerinde
psikiyatrik ilaç kullanım öyküsü varken, erkek hastaların 38 (%15,3)’inde
psikiyatrik ilaç kullanım öyküsü vardı. İlaç intoksikasyon vakalarının
çoğunluğu (%45,9 hasta) ilköğretim mezunu idi. Çalışmaya alınan hastaların
büyük bir çoğunluğu (%24,7) antidepresan ilaçlarla zehirlenme görülürken,
ikinci sırada (%18,3) parasetamol ile zehirlenmeler yer almaktaydı. Hastaların
%82.4’ünde intihar amaçlı ilaç alım öyküsü vardı. Hastaların 138 (%55,6)
tanesinde tek grup ilaç alım öyküsü varken, hastaların 71 (%28,6) tanesi
hastanede bir gün gözlem altında kalmıştır. 248 hastanın sadece 13 (%5,2)
tanesinde genel durumunda bozulma olması nedeni ile yoğun bakım servislerine
nakledilmiştir.
Sonuç:
İntoksikasyon
vakalarının çoğunluğunu genç bayanların oluşturduğunu ve özellikle intihar
amaçlı antidepresan ilaçlarla olduğu görülmüştür.
References
- 1) Akköse Ş, Fedakar R, Bulut M, Çebicci H. Zehirlenme olgularınınn beş yıllık analizi. Acil Tıp Dergisi 2003; 3 (1): 8-10.2) Yavuz S, Aydın S. Zehirlenme olgularının profili.Toksikoloji Dergisi 2003; 1 (1): 47-52.3) Meredith TJ. Epidemiology of poisoning. Pharmacol Ther 1993; 59: 251-56.4) Litovitz TL, Klein-Schwartz W, Dyer KS, et al. 1997 annual report of the American Association of Poison Control Centers Toxic Exposure Surveillance System. Am J Emerg Med 1998; 16: 443-975) Gunnell D, Eddleston M. Suicide by intentional ingestion of pesticides: a continuing tragedy in developing countries. Int J Epidemiol, 2003; 32: 902 -09.6) Henderson A, Wright M, Pond SM. Experience with acute overdose patients admitted to an intensive unit over six years. Med J Aust 1993; 158: 28-30. 7) Pekdemir M, Kavalcı C, Durukan P. ve ark. Acil Servisimize Başvuran Zehirlenme olgularının değerlendirilmesi. Acil Tıp Dergisi 2002; 2: 36-40.8) Karcıoğlu O, Demirel Y, Esener Z, et al. Drug intoxication in the emergency department: a one year case series. Acil Tıp Dergisi 2002; 2: 26-32.9) Kekec Z, Yavuz Y, Kurtoğlu S, et al. Two year evaluation of pediatric poisoning cases presenting to our pediatric department. Acil Tıp Dergisi 2002; 2: 33-37.10) Fuller GN, Rea AJ, Payne JF, Lant AF. Parasuicide in central London 1984-1988. J R Soc Med 1989; 82: 653-656. 11) Staikowsky F, Uzan D, Grillon N, et al. Voluntary drug poisoning cases admitted to an emergency care unit. Presse Med 1995; 24: 1296-1300. 12) Beskow J. Depression and suicide. Pharmaco psychi¬atry 1990; 23: 3-8. 13) Cheng AT. Mental illness and suicide. A case-control study in East Taiwan. Arch Gen Psychiatry 1995; 52: 594-603. 14) Kasper S, Schindler S, Neumister A. Risk of suicide in depression and it simplication for psychopharmacological treatment. Int Clin Psychopharmacol 1996; 11: 71-77. 15) Abdollahi M, Jalali N, Sabzevari O, Hoseini R, Ghanea T. A retrospective study of poisoning in Tehran. J Toxi¬col Clin Toxicol 1997; 35: 387-393. 16) Yağan O, Akan B, Erdem D, et al. The retrospective analysis of the acute poisoning cases applying to the emergency unit in one year. Şişli Etfal Hastanesi Tıp Bulteni 2009; 43: 60-64.17) Kurt I, Erpek AG, Kurt MN, et al. Epidemiology of adult poisoning at the Adnan Menderes University. ADU Tıp Fakultesi Dergisi 2004; 5: 37-40.18) DoradoPombo S, Martin Fernandez J, SabugalRodelgo G, CaballeroValles PJ. Epidemiology of acutepoisoning: study of 613 cases in the Community of Madrid in 994.Rev ClinEsp 1996; 196: 150-156.19) Seydaoglu G, Satar S, Alparslan N. Frequency and mortality risk factors of acute adult poisoning in Adana, Turkey, 1997- 2002. Mt Sinai J Med 2005; 72: 393-401.20) Akkas M, Coskun F, Ulu N, et al. An epidemiological evaluation of 1098 acute poisoning cases from Turkey. Vet Hum Toxicol 2004; 46: 213-215.21) Ozayar E, Degerli S, Gulec H, Sahin S, Dereli N. Retrospective Analysis of Intoxication Cases in the ICU. Dahili ve Cerrahi Bilimler Yoğun Bakım Dergisi/ Turkish J Med Surg Inten Care. 2011; 2(3): 59-62.22) Kaygusuz K, Gürsoy S, Kılıçcıoğlu F, Özdemirkol İ, Mimaroğlu C. Cumhuriyet Üniversitesi Tıp Fakültesi Hastanesi Yoğun Bakım Ünitesinde 1998-2004 Yılları Arasında Akut İlaç Zehirlenmesi Tanısı İle Takip Edilen Olguların Geriye Dönük Analizi. CÜ Tıp Fak Derg. 2004; 26(4): 161-165.
Abstract
Aim:
The aim of our study was to evaluate the patients who were admitted to the
emergency department as drug intoxication and then followed up and treated in
the internal medicine department with regard to their demographic
characteristics, the drugs they received for intoxication and their prognosis.
Material
and Method: The study included 248 patients who were followed-up and
treated in the Internal Medicine Department for drug intoxication between
2013-2018. Patients were evaluated in terms of gender and age characteristics,
psychiatric drug use history, educational status, the nature of the drugs they
received for intoxication, the number of drugs they received, their prognosis
and length of hospital stay.
Results:
The study included 248 patients who were followed up and treated as drug
intoxication in the Internal Diseases service. Of these patients, 161 (64.9%)
were female and 87 (35.1%) were male. The mean age was 27.8 ± 14.7 (18-64)
years in female patients and 24.2 ± 13.8 (18-53) years in male patients. While
108 (43.5%) of the female patients were single, 64 (25.8%) of the male patients
were single. While 91 (36.6%) of the female patients had a history of
psychiatric medication in their background, 38 (15.3%) of the male patients had
a history of psychiatric medication use. The majority of cases of drug
intoxication (45.9% of patients) were primary school graduates. The majority of
the patients (24.7%) were poisoned with antidepressant drugs, while the second
group (18.3%) had paracetamol poisonings. 82.4% of the patients had a history
of taking suicidal drugs. In 138 (55.6%) patients, there was only one group of
medications. Of the patients, 71 (28.6%) were hospitalized for one day. Of the
248 patients, only 13 (5.2%) were transferred to the intensive care unit due to
the deterioration in their general condition.
Conclusion:
The majority of cases of intoxication were found to be young women,
especially with antidepressant drugs intended for suicide.
References
- 1) Akköse Ş, Fedakar R, Bulut M, Çebicci H. Zehirlenme olgularınınn beş yıllık analizi. Acil Tıp Dergisi 2003; 3 (1): 8-10.2) Yavuz S, Aydın S. Zehirlenme olgularının profili.Toksikoloji Dergisi 2003; 1 (1): 47-52.3) Meredith TJ. Epidemiology of poisoning. Pharmacol Ther 1993; 59: 251-56.4) Litovitz TL, Klein-Schwartz W, Dyer KS, et al. 1997 annual report of the American Association of Poison Control Centers Toxic Exposure Surveillance System. Am J Emerg Med 1998; 16: 443-975) Gunnell D, Eddleston M. Suicide by intentional ingestion of pesticides: a continuing tragedy in developing countries. Int J Epidemiol, 2003; 32: 902 -09.6) Henderson A, Wright M, Pond SM. Experience with acute overdose patients admitted to an intensive unit over six years. Med J Aust 1993; 158: 28-30. 7) Pekdemir M, Kavalcı C, Durukan P. ve ark. Acil Servisimize Başvuran Zehirlenme olgularının değerlendirilmesi. Acil Tıp Dergisi 2002; 2: 36-40.8) Karcıoğlu O, Demirel Y, Esener Z, et al. Drug intoxication in the emergency department: a one year case series. Acil Tıp Dergisi 2002; 2: 26-32.9) Kekec Z, Yavuz Y, Kurtoğlu S, et al. Two year evaluation of pediatric poisoning cases presenting to our pediatric department. Acil Tıp Dergisi 2002; 2: 33-37.10) Fuller GN, Rea AJ, Payne JF, Lant AF. Parasuicide in central London 1984-1988. J R Soc Med 1989; 82: 653-656. 11) Staikowsky F, Uzan D, Grillon N, et al. Voluntary drug poisoning cases admitted to an emergency care unit. Presse Med 1995; 24: 1296-1300. 12) Beskow J. Depression and suicide. Pharmaco psychi¬atry 1990; 23: 3-8. 13) Cheng AT. Mental illness and suicide. A case-control study in East Taiwan. Arch Gen Psychiatry 1995; 52: 594-603. 14) Kasper S, Schindler S, Neumister A. Risk of suicide in depression and it simplication for psychopharmacological treatment. Int Clin Psychopharmacol 1996; 11: 71-77. 15) Abdollahi M, Jalali N, Sabzevari O, Hoseini R, Ghanea T. A retrospective study of poisoning in Tehran. J Toxi¬col Clin Toxicol 1997; 35: 387-393. 16) Yağan O, Akan B, Erdem D, et al. The retrospective analysis of the acute poisoning cases applying to the emergency unit in one year. Şişli Etfal Hastanesi Tıp Bulteni 2009; 43: 60-64.17) Kurt I, Erpek AG, Kurt MN, et al. Epidemiology of adult poisoning at the Adnan Menderes University. ADU Tıp Fakultesi Dergisi 2004; 5: 37-40.18) DoradoPombo S, Martin Fernandez J, SabugalRodelgo G, CaballeroValles PJ. Epidemiology of acutepoisoning: study of 613 cases in the Community of Madrid in 994.Rev ClinEsp 1996; 196: 150-156.19) Seydaoglu G, Satar S, Alparslan N. Frequency and mortality risk factors of acute adult poisoning in Adana, Turkey, 1997- 2002. Mt Sinai J Med 2005; 72: 393-401.20) Akkas M, Coskun F, Ulu N, et al. An epidemiological evaluation of 1098 acute poisoning cases from Turkey. Vet Hum Toxicol 2004; 46: 213-215.21) Ozayar E, Degerli S, Gulec H, Sahin S, Dereli N. Retrospective Analysis of Intoxication Cases in the ICU. Dahili ve Cerrahi Bilimler Yoğun Bakım Dergisi/ Turkish J Med Surg Inten Care. 2011; 2(3): 59-62.22) Kaygusuz K, Gürsoy S, Kılıçcıoğlu F, Özdemirkol İ, Mimaroğlu C. Cumhuriyet Üniversitesi Tıp Fakültesi Hastanesi Yoğun Bakım Ünitesinde 1998-2004 Yılları Arasında Akut İlaç Zehirlenmesi Tanısı İle Takip Edilen Olguların Geriye Dönük Analizi. CÜ Tıp Fak Derg. 2004; 26(4): 161-165.
Details
| Primary Language | Turkish |
|---|---|
| Subjects | Health Care Administration |
| Journal Section | Original Article |
| Authors | |
| Publication Date | September 22, 2019 |
| Published in Issue | Year 2019 Volume: 2 Issue: 4 |
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