Araştırma Makalesi
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Analysis of Radiation Dose Distribution Inhomogenity Effects in Gamma Knife Radiosurgery using Geant4

Yıl 2022, Cilt: 25 Sayı: 1, 59 - 64, 01.03.2022
https://doi.org/10.2339/politeknik.674718

Öz

The Monte Carlo method is widely used in the Gamma Knife dose distribution calculations. In this study, Monte-Carlo simulation with Geant4 was applied to determine Leksell Gamma Knife dose distribution for homogeneous solid water and heterogeneous brain phantoms, and primarily focused on the differences arising from the effects of inhomogeneity. The relative dose graphs were displayed for different collimator diameters. The dose values from the maximal interval regions were determined and compared. It seen that when the collimator size was 4mm, the mean maximum relative dose point was at 47mm for water phantom and at 44mm for the brain. The difference found was about 6.38%. The differences among the results determined for water and brain were ranged from 2 to 17%. As a result, the inhomogeneity effect should be considered in dose calculation in Gamma Knife planning system.

Kaynakça

  • [1] Leksell, L., "The stereotaxic method and radiosurgery of the brain". Acta Chir Scand, 102:316–319, (1951).
  • [2] Elekta "Leksell GammaPlan Instructions for use for version 4.0-Target Series". Elekta, Geneva (1996).
  • [3] Solberg, T., DeMacro, J., Holly, F., Smathers, J. and DeSalles A., "Monte Carlo treatment planning for stereotactic radiosurgery". Radioth and Onco 49:73–84, (1998).
  • [4] Xiong, W., Huang, D., Lee, L., Feng, J., Morris, K., Calugaru, E., Burman, E., Li, J. and Ma C-M., ''Implementation of Monte Carlo simulations for the gamma knife system. First European workshop on Monte Carlo Treatment Planning.'' In: Journal of Physics: Conference Series 74, 2023, (2007).
  • [5] ICRU Report 62 Prescribing, Recording and Reporting Photo Beam Therapy (Supplement to ICRU Report 50), Bethesda, MD, (1999).
  • [6] Xiaowei, L., Chunxiang Z Simulation of dose distribution irradiation by the Leksell Gamma unit. Phys Med Biol 44: 441–445, (1999).
  • [7] Al-Dweri, F.M.O., Lallena, A.M., Vilches, M., A simplified model of the source channel of the Leksell GammaKnife tested with PENELOPE. Phys Med Biol 49:2687–2703 .
  • [8] Al-Dweri, F.M.O., Lallena, A.M., A simplified model of the source channel of the Leksell Gamma Knife: testing multisource configurations with PENELOPE. Phys Med Biol 49:3441–3453, (2004).
  • [9] Cheung, J.Y.C., Yu, K.N., Ho, R.Y.C., Stereotactic doseplanning system used in Leksell Gamma Knife model-B: EGS4 Monte Carlo versus GafChromic films MD-55. Appl Radiat Isot 53:427–430, (2000).
  • [10]https://physics.nist.gov/cgibin/Star/compos.pl?refer=ap&matno=276
  • [11] https://physics.nist.gov/cgibin/Star/compos.pl?matno=123
  • [12] Li, J.S., Ma, C.M., A method to reduce the statistical uncertainty caused by high-energy cutoffs in Monte Carlo treatment planning. J Phys Conf Ser (2008)102:.
  • [13] Bertolino, N., "Experimental validation of Monte Carlo simulation of Leksell Gamma Knife Perfexion stereotactic radiosurgery system". PhD Thesis, Università Degli Studi Di Milano (2009).
  • [14] Moskvin, V., Timmerman, R., DesRosiers, C., et al. Monte carlo simulation of the Leksell Gamma Knife: II. Effects of heterogeneous versus homogeneous media for stereotactic radiosurgery. Phys Med Biol 49:4879–95, (2004).
  • [15] Moskvin, V., DesRosiers, C., Papiez, L., et al. Monte Carlo simulation of the Leksell Gamma Knife: I. Source modelling and calculations in homogeneous media. Phys Med Biol, 47:1995–2011, (2002).
  • [16] Cheung, J.Y.C., Yu, K.N., Ho, R.T.K. and Yu, C., Monte Carlo calculated output factors of a Leksell Gamma Knife unit. Phys Med Biol, 44:N247–N249, (1999).
  • [17] Cheung, J.Y.C., Yu, K.N., Yu, C.P., Ho, R.T.K., Monte Carlo calculation of single-beam dose profiles used in a gamma knife treatment planning system. Med Phys 25:1673–1675, (1998).
  • [18] Cheung, J.Y., Yu, K.N., Ho, R.T., Yu, C.P., Monte Carlo calculations and GafChromic film measurements for plugged collimator helmets of Leksell Gamma Knife unit. Med Phys 26:1252–1256, (1999).
  • [19] AAPM Task Group 21 A protocol for the determination of absorbed dose from high-energy photon and electron beams. Med. Phys, 10:741–771 (1983).
  • [20] Cuttone, G., Mongelli, V., Romano, F., Russo, G., Sabini M Geant4 based simulation of the Leksell Gamma Knife for treatment planning validations. In: 14th Geant4 Users and Collaboration Workshop. Catania, Italy, (2009).

Analysis of Radiation Dose Distribution Inhomogenity Effects in Gamma Knife Radiosurgery using Geant4

Yıl 2022, Cilt: 25 Sayı: 1, 59 - 64, 01.03.2022
https://doi.org/10.2339/politeknik.674718

Öz

The Monte Carlo method is widely used in the Gamma Knife dose distribution calculations. In this study, Monte-Carlo simulation with Geant4 was applied to determine Leksell Gamma Knife dose distribution for homogeneous solid water and heterogeneous brain phantoms, and primarily focused on the differences arising from the effects of inhomogeneity. The relative dose graphs were displayed for different collimator diameters. The dose values from the maximal interval regions were determined and compared. It seen that when the collimator size was 4mm, the mean maximum relative dose point was at 47mm for water phantom and at 44mm for the brain. The difference found was about 6.38%. The differences among the results determined for water and brain were ranged from 2 to 17%. As a result, the inhomogeneity effect should be considered in dose calculation in Gamma Knife planning system.

Kaynakça

  • [1] Leksell, L., "The stereotaxic method and radiosurgery of the brain". Acta Chir Scand, 102:316–319, (1951).
  • [2] Elekta "Leksell GammaPlan Instructions for use for version 4.0-Target Series". Elekta, Geneva (1996).
  • [3] Solberg, T., DeMacro, J., Holly, F., Smathers, J. and DeSalles A., "Monte Carlo treatment planning for stereotactic radiosurgery". Radioth and Onco 49:73–84, (1998).
  • [4] Xiong, W., Huang, D., Lee, L., Feng, J., Morris, K., Calugaru, E., Burman, E., Li, J. and Ma C-M., ''Implementation of Monte Carlo simulations for the gamma knife system. First European workshop on Monte Carlo Treatment Planning.'' In: Journal of Physics: Conference Series 74, 2023, (2007).
  • [5] ICRU Report 62 Prescribing, Recording and Reporting Photo Beam Therapy (Supplement to ICRU Report 50), Bethesda, MD, (1999).
  • [6] Xiaowei, L., Chunxiang Z Simulation of dose distribution irradiation by the Leksell Gamma unit. Phys Med Biol 44: 441–445, (1999).
  • [7] Al-Dweri, F.M.O., Lallena, A.M., Vilches, M., A simplified model of the source channel of the Leksell GammaKnife tested with PENELOPE. Phys Med Biol 49:2687–2703 .
  • [8] Al-Dweri, F.M.O., Lallena, A.M., A simplified model of the source channel of the Leksell Gamma Knife: testing multisource configurations with PENELOPE. Phys Med Biol 49:3441–3453, (2004).
  • [9] Cheung, J.Y.C., Yu, K.N., Ho, R.Y.C., Stereotactic doseplanning system used in Leksell Gamma Knife model-B: EGS4 Monte Carlo versus GafChromic films MD-55. Appl Radiat Isot 53:427–430, (2000).
  • [10]https://physics.nist.gov/cgibin/Star/compos.pl?refer=ap&matno=276
  • [11] https://physics.nist.gov/cgibin/Star/compos.pl?matno=123
  • [12] Li, J.S., Ma, C.M., A method to reduce the statistical uncertainty caused by high-energy cutoffs in Monte Carlo treatment planning. J Phys Conf Ser (2008)102:.
  • [13] Bertolino, N., "Experimental validation of Monte Carlo simulation of Leksell Gamma Knife Perfexion stereotactic radiosurgery system". PhD Thesis, Università Degli Studi Di Milano (2009).
  • [14] Moskvin, V., Timmerman, R., DesRosiers, C., et al. Monte carlo simulation of the Leksell Gamma Knife: II. Effects of heterogeneous versus homogeneous media for stereotactic radiosurgery. Phys Med Biol 49:4879–95, (2004).
  • [15] Moskvin, V., DesRosiers, C., Papiez, L., et al. Monte Carlo simulation of the Leksell Gamma Knife: I. Source modelling and calculations in homogeneous media. Phys Med Biol, 47:1995–2011, (2002).
  • [16] Cheung, J.Y.C., Yu, K.N., Ho, R.T.K. and Yu, C., Monte Carlo calculated output factors of a Leksell Gamma Knife unit. Phys Med Biol, 44:N247–N249, (1999).
  • [17] Cheung, J.Y.C., Yu, K.N., Yu, C.P., Ho, R.T.K., Monte Carlo calculation of single-beam dose profiles used in a gamma knife treatment planning system. Med Phys 25:1673–1675, (1998).
  • [18] Cheung, J.Y., Yu, K.N., Ho, R.T., Yu, C.P., Monte Carlo calculations and GafChromic film measurements for plugged collimator helmets of Leksell Gamma Knife unit. Med Phys 26:1252–1256, (1999).
  • [19] AAPM Task Group 21 A protocol for the determination of absorbed dose from high-energy photon and electron beams. Med. Phys, 10:741–771 (1983).
  • [20] Cuttone, G., Mongelli, V., Romano, F., Russo, G., Sabini M Geant4 based simulation of the Leksell Gamma Knife for treatment planning validations. In: 14th Geant4 Users and Collaboration Workshop. Catania, Italy, (2009).
Toplam 20 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Mühendislik
Bölüm Araştırma Makalesi
Yazarlar

Özlem Dağlı 0000-0003-3798-8342

Ayşe Güneş Tanır, Ph.d. 0000-0001-8966-7458

Gökhan Kurt Bu kişi benim 0000-0002-2773-056X

Yayımlanma Tarihi 1 Mart 2022
Gönderilme Tarihi 14 Ocak 2020
Yayımlandığı Sayı Yıl 2022 Cilt: 25 Sayı: 1

Kaynak Göster

APA Dağlı, Ö., Tanır, Ph.d., A. G., & Kurt, G. (2022). Analysis of Radiation Dose Distribution Inhomogenity Effects in Gamma Knife Radiosurgery using Geant4. Politeknik Dergisi, 25(1), 59-64. https://doi.org/10.2339/politeknik.674718
AMA Dağlı Ö, Tanır, Ph.d. AG, Kurt G. Analysis of Radiation Dose Distribution Inhomogenity Effects in Gamma Knife Radiosurgery using Geant4. Politeknik Dergisi. Mart 2022;25(1):59-64. doi:10.2339/politeknik.674718
Chicago Dağlı, Özlem, Ayşe Güneş Tanır, Ph.d., ve Gökhan Kurt. “Analysis of Radiation Dose Distribution Inhomogenity Effects in Gamma Knife Radiosurgery Using Geant4”. Politeknik Dergisi 25, sy. 1 (Mart 2022): 59-64. https://doi.org/10.2339/politeknik.674718.
EndNote Dağlı Ö, Tanır, Ph.d. AG, Kurt G (01 Mart 2022) Analysis of Radiation Dose Distribution Inhomogenity Effects in Gamma Knife Radiosurgery using Geant4. Politeknik Dergisi 25 1 59–64.
IEEE Ö. Dağlı, A. G. Tanır, Ph.d., ve G. Kurt, “Analysis of Radiation Dose Distribution Inhomogenity Effects in Gamma Knife Radiosurgery using Geant4”, Politeknik Dergisi, c. 25, sy. 1, ss. 59–64, 2022, doi: 10.2339/politeknik.674718.
ISNAD Dağlı, Özlem vd. “Analysis of Radiation Dose Distribution Inhomogenity Effects in Gamma Knife Radiosurgery Using Geant4”. Politeknik Dergisi 25/1 (Mart 2022), 59-64. https://doi.org/10.2339/politeknik.674718.
JAMA Dağlı Ö, Tanır, Ph.d. AG, Kurt G. Analysis of Radiation Dose Distribution Inhomogenity Effects in Gamma Knife Radiosurgery using Geant4. Politeknik Dergisi. 2022;25:59–64.
MLA Dağlı, Özlem vd. “Analysis of Radiation Dose Distribution Inhomogenity Effects in Gamma Knife Radiosurgery Using Geant4”. Politeknik Dergisi, c. 25, sy. 1, 2022, ss. 59-64, doi:10.2339/politeknik.674718.
Vancouver Dağlı Ö, Tanır, Ph.d. AG, Kurt G. Analysis of Radiation Dose Distribution Inhomogenity Effects in Gamma Knife Radiosurgery using Geant4. Politeknik Dergisi. 2022;25(1):59-64.

Cited By

Geant4 based dosimetry evaluation for gamma knife using different phantom materials
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